VICODIN ES 7.5 mg/750 mg: The usual adult dosage of vicodin 750 mg is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 5 tablets. VICODIN HP 10 mg/660 mg: The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 6 tablets .The usual adult dosage of 750 mg vicodin is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 5 tablets. If you have ongoing pain (such as due to cancer), your doctor may direct you to also take long-acting opioid medications. In that case, this medication might be used for sudden (breakthrough) pain only as needed. Other pain relievers (such as ibuprofen, naproxen) may also be prescribed. Ask your doctor or pharmacist about using this product safely with other drugs.